Nursing Pharmacology: Adrenergic Pharmacology

 
 
 

 

Nursing Pharmacology Chapter 5:  Autonomic Pharmacology--Adrenergic Drugs

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Introduction

 

Adrenergic Agonists

 

Comparative Sympathomimetic Pharmacology

Drug

α

β1

β2

Mechanism of action

Peripheral resistance

Renal blood flow

Mean arterial pressure

CNS stimulation

Epinephrine

Direct

+/-

Yes

Norepinephrine (Levophed)

0

Direct

No

Dopamine (Intropin)

Direct

No

Isoproterenol (Isuprel)

0

Direct

+/-

Yes

Dobutamine (Dobutrex)

0

0

Direct

NC

 

Ephedrine

Direct+Indirect

Yes

Mephentermine (Wyamine)

Direct+Indirect

Yes

Amphetamines

Indirect

Yes

Metaraminol (Aramine)

Indirect+direct

No

Phenylephrine (Neo-Synephrine)

methoxamine (Vasoxyl)

0

0

Direct

No

--increased effect; --decreased effect

(adapted from: Table 12-1 Stoelting, R.K., "Pharmacokinetics and Pharmacodynamics of Injected and Inhaled Drugs", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, p. 260)

 

Categories of Action

Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.199-242

Stoelting, R.K., "Sympathomimetics", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, p. 260

 

 
 
 

 

 

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